小型猪专用复合麻醉剂对大鼠不同脑区β-arrestin2基因mRNA转录的影响

doi:10.11843/j.issn.0366-6964.2014.05.024

Abstract

Abstract:

In order to investigate the Transcription of β-arrestin2 mRNA in different encephalic regions of rats anesthetized with the Combined Anaesthetic for Miniature Pigs（named as XFM)， 30 rats were divided randomly into two groups: the control group and XFM groups．XFM groups consisted of four subgroups：M₁subgroup（ rats received XFM intraperitoneally and then waiting the disappearance of right reflection)；M₂subgroup（rats received XFM intraperitoneally and then waiting for 1 h after the disappearance of right reflection)；M₃ subgroup（rats received XFM intraperitoneally and then waiting the recovery of right reflection) and M₄ subgroup（rats received XFM intraperitoneally and then waiting for 1 h after the recovery of right reflection)．The brain tissues were taken when reaching each time point．The transcription of β-arrestin2 mRNA in central nervous system was detected with real time PCR．The results showed that the transcription of β-arrestin2 mRNA in cerebral cortex and cerebellum decreased significantly after receiving XFM（P<0.01)；the transcription of β-arrestin2 mRNA in hippocampus and brain stem increased significantly（P<0.01)．These results indicated that XFM could affect the transcription of β-arrestin2 mRNA in central nervous system．This might be one of the anaesthetic mechanisms for XFM．And it will lay the foundation of continuing to explore anesthesia for the effects of MAPK pathway．

CLC Number:

S859.791

NIU Dong-liang， JIANG Sheng， LI Xin， CHEN Hao， FAN Hong-gang， WANG Hong-bin. The Transcription of β-arrestin2 mRNA in Different Encephalic Regions of Rats Anesthetized with the Combined Anaesthetic for Miniature Pigs[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2014, 45(5): 839-843.

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The Transcription of β-arrestin2 mRNA in Different Encephalic Regions of Rats Anesthetized with the Combined Anaesthetic for Miniature Pigs

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